Telomeres, Atherosclerosis, and Human Longevity

Human telomere length, as expressed in leukocytes, is strongly fashioned by heritability. A number of genes that explain some of the inter-individual variation in leukocyte telomere length have already been identified. Leukocyte telomere length is longer in women than in men and in African Americans than in whites of european descent. in addition, offspring of older fathers display a longer leukocyte telomere length, a finding that may reflect longer telomeres in sperm of older men. in contrast to the male germline, telomeres in replicative somatic tissues, including the hematopoietic system, display age-dependent shortening. A shorter leukocyte telomere length is associated with aging-related diseases, principally atherosclerosis and reduced longevity. the prevailing interpretation is that a shorter leukocyte telomere length is the outcome of processes, mainly the age-dependent accruing burden of oxidative stress and inflammation that ultimately shorten the human lifespan. As such, leukocyte telomere length is considered to be a non-causal biomarker, ie, a telomeric “clock,” of human aging. We propose that telomere length is not only associated with atherosclerosis and longevity but is also a causal determinant of both. this hypothesis is based on a model of leukocyte telomere length dynamics (leukocyte telomere length and its attrition rate) that incorporates two key features. First, the model differentiates the findings of studies of telomere length dynamics in vitro from those in vivo. second, the model distinguishes two phases of human leukocyte telomere length dynamics in vivo: growth and adulthood.